What question did this study set out to answer?

To determine the clinical, virological, and immunological characteristics of an echovirus type 11 outbreak occurring among newborns in a maternity unit.

January 1, 1975Japanese Journal of Medical Science and BiologyOpen Access

Virologic and Serologic Studies on an Outbreak of Echovirus Type 11 Infection in a Hospital Maternity Unit

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Population

188 newborn babies born between July 21 and October 9, 1971, in a hospital maternity unit in Tokyo, Japan…

Design

Case_series

Authors

AHAyako HasegawaNara Medical University

Discussion

Member takes

Implication

Highlights outbreak risk from echovirus 11 variants in maternity units; leaves open the protective role of 19S-dominant neonatal responses.

Key Points

To determine the clinical, virological, and immunological characteristics of an echovirus type 11 outbreak occurring among newborns in a maternity unit.
Monitored 188 infants in a hospital maternity unit during a 1.5-month outbreak between July and September 1971.
Collected stool specimens and throat swabs for viral isolation, and evaluated serum neutralizing antibody titers in infants and mothers.
Performed cross-neutralization tests and sucrose gradient centrifugation to determine strain antigenic variation and antibody sedimentation fractions.
Febrile illness with stomatitis developed in 41 of 188 infants (21.8%), with virus isolated from 14 stool specimens and 2 throat swabs, and seroconversion detected in all 19 infants tested.
The isolated echovirus type 11 was an antigenic variant not neutralized by prototype antiserum, whereas antiserum against the isolate neutralized both the isolate and prototype Gregory strain.
Neutralizing antibody activity in infant sera localized predominantly to the 19S fraction rather than the 7S fraction, displaying greater specificity for the outbreak strain.

Structured PICO

Population

188 newborn babies born between July 21 and October 9, 1971, in a hospital maternity unit in Tokyo, Japan. 41 developed febrile illness with stomatitis (ages 3 to 21 days at onset).

Outcome

Virologic and serologic characterization of the echovirus type 11 outbreak, including virus isolation and neutralizing antibody titers in 19S and 7S fractions.surrogate

The study characterizes an outbreak of an antigenic variant of echovirus type 11 in a maternity unit, demonstrating that newborn infants can mount a primary immune response predominantly of the 19S antibody type.

Cite This Study

Ayako Hasegawa (1975) studied this question.

synapsesocial.com/papers/6a8c091bf71fc1553cbeb184 https://doi.org/10.7883/yoken1952.28.179

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Implication

Highlights outbreak risk from echovirus 11 variants in maternity units; leaves open the protective role of 19S-dominant neonatal responses.

Virologic and Serologic Studies on an Outbreak of Echovirus Type 11 Infection in a Hospital Maternity Unit

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Virologic and Serologic Studies on an Outbreak of Echovirus Type 11 Infection in a Hospital Maternity Unit

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider