Key result
Type 2 diabetes was not independently associated with the presence of coronary artery calcification after adjusting for traditional risk factors (OR 1.0), and over one-third of diabetic patients had no calcification.
Why the study?
Does type 2 diabetes mellitus independently associate with the presence of coronary artery calcification in a randomly selected population?
Population
1,211 randomly selected Danish men and women, aged 50 or 60 years, including 54 with type 2 diabetes…
Comparison
Non-contrast 64-slice CT scan for coronary… vs Subjects without diabetes (n=1,157)
Design
Cross-sectional, Agatston score was calculated by experienced cardiologists…
Authors
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T2D not independently tied to CAC after adjustment; leaves open whether diabetes-specific risk models improve stratification beyond traditional factors.
Cross-Sectional (n=1,211)
Yes
Does type 2 diabetes mellitus independently associate with the presence of coronary artery calcification in a randomly selected population?
Odds Ratio: 1 (95% CI 0.5–2)
Absolute Event Rate: 62% vs 44%
p-value: p=0.94
One-third of patients with type 2 diabetes do not have coronary artery calcification, and T2D itself is not independently associated with CAC when adjusting for traditional risk factors, suggesting individualized cardiovascular risk stratification is needed.
Tofterup et al. (2015) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=1,211). Type 2 Diabetes Mellitus vs. Individuals without diabetes was evaluated on Presence of coronary artery calcification (CAC > 0) (OR 1.0, 95% CI 0.5-2.0, p=0.94). Type 2 diabetes was not independently associated with the presence of coronary artery calcification after adjusting for traditional risk factors (OR 1.0), and over one-third of diabetic patients had no calcification.
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