April 1, 1999Journal of VirologyOpen Access

Foamy Virus Capsids Require the Cognate Envelope Protein for Particle Export

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Population

Human foamy virus (HFV) capsids and envelope (Env) glycoprotein mutants

Comparison

Deletion and point mutations of the HFV Env… vs Wild-type HFV Env

Design

Preclinical

Authors

TPThomas PietschmannMedizinische Hochschule Hannover MHMartin HeinkeleinUniversity of Würzburg MHMartina HeldmannUniversity of Würzburg

Discussion

Member takes

Implication

No immediate clinical implications; leaves open Env domain targeting for foamy virus control.

Structured PICO

Population

Human foamy virus (HFV) capsids and envelope (Env) glycoprotein mutants

Intervention

Deletion and point mutations of the HFV Env protein, pseudotyping with MuLV Env and VSV-G

Comparator

Wild-type HFV Env

Outcome

Viral particle envelopment, release, and infectivity

The study demonstrates that human foamy virus capsids specifically require their cognate envelope protein, particularly the membrane-spanning domain, for viral particle egress.

Cite This Study

Pietschmann et al. (1999) studied this question.

synapsesocial.com/papers/6a8c0f04f8241cb45bfb7e4a https://doi.org/10.1128/jvi.73.4.2613-2621.1999

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April 1, 1999Journal of VirologyOpen Access

Foamy Virus Capsids Require the Cognate Envelope Protein for Particle Export

View Full Paper

Ask AI

Bookmark

Population

Human foamy virus (HFV) capsids and envelope (Env) glycoprotein mutants

Comparison

Deletion and point mutations of the HFV Env… vs Wild-type HFV Env

Design

Preclinical

Authors

TPThomas PietschmannMedizinische Hochschule Hannover MHMartin HeinkeleinUniversity of Würzburg MHMartina HeldmannUniversity of Würzburg

Discussion

Member takes

Implication

No immediate clinical implications; leaves open Env domain targeting for foamy virus control.

Structured PICO

Population

Human foamy virus (HFV) capsids and envelope (Env) glycoprotein mutants

Intervention

Deletion and point mutations of the HFV Env protein, pseudotyping with MuLV Env and VSV-G

Comparator

Wild-type HFV Env

Outcome

Viral particle envelopment, release, and infectivity

The study demonstrates that human foamy virus capsids specifically require their cognate envelope protein, particularly the membrane-spanning domain, for viral particle egress.

Cite This Study

Pietschmann et al. (1999) studied this question.

synapsesocial.com/papers/6a8c0f04f8241cb45bfb7e4a https://doi.org/10.1128/jvi.73.4.2613-2621.1999

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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