Key result
Severe aortic valve stenosis was associated with significantly higher serum ADMA activity compared to mild stenosis (1.94 vs 0.87 micromol/l, P<0.001).
Why the study?
Is plasma asymmetrical dimethylarginine (ADMA) activity associated with the severity of aortic valve stenosis?
Observational (n=109)
Is plasma asymmetrical dimethylarginine (ADMA) activity associated with the severity of aortic valve stenosis?
Absolute Event Rate: 1.94% vs 0.87%
p-value: p=<0.001
Serum ADMA activity is significantly elevated in severe aortic valve stenosis and correlates with echocardiographic markers of severity.
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ADMA may mark aortic stenosis severity; hypothesis-generating and requires prospective validation before clinical use.
Çay et al. (2010) conducted an observational in Aortic valve stenosis (n=109). Severe aortic valve stenosis vs. Mild aortic valve stenosis was evaluated on Mean ADMA activity (micromol/l) (p=<0.001). Severe aortic valve stenosis was associated with significantly higher serum ADMA activity compared to mild stenosis (1.94 vs 0.87 micromol/l, P<0.001).
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