Key result
Nonstenotic bicuspid aortic valve linked to ~28% higher plasma ADMA levels versus controls.
Why the study?
Nonstenotic bicuspid aortic valve with dilated proximal aorta is linked with increased MMP-2 and endothelial dysfunction, but the role of ADMA and its association with aortic dilatation in BAV patients is unclear.
Case-Control (n=40)
Absolute Event Rate: 0.55% vs 0.43%
p-value: p=<0.001
Elevated plasma ADMA and MMP-2 levels are associated with proximal ascending aortic dilatation and impaired aortic elastic properties in patients with nonstenotic bicuspid aortic valve.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications for nonstenotic BAV; hypothesis-generating for ADMA as endothelial marker and requires outcome validation.
Drapisz et al. (2013) conducted a case-control in Nonstenotic bicuspid aortic valve (n=40). Nonstenotic bicuspid aortic valve vs. Tricuspid aortic valves was evaluated on Plasma levels of ADMA (p=<0.001). Nonstenotic bicuspid aortic valve was associated with significantly higher plasma ADMA levels compared to controls (median 0.55 vs. 0.43 μmol/l, P<0.001).
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