Why the study?
Does the presence of ischaemic events on Holter monitoring predict hard or soft clinical endpoints in patients with chronic stable angina treated with atenolol, nifedipine SR, or their combination?
Population
682 men and women with a diagnosis of chronic stable angina who were not being considered for surgery
Comparison
Atenolol, nifedipine SR, or their combination vs Active comparators
Design
RCT, Randomized parallel group, Double-blind
Follow-up
2 years on average
Authors
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Holter ischaemia lacks prognostic value in stable angina; challenges reliance on ambulatory monitoring for risk stratification and prioritizes clinical over surrogate endpoints.
Does the presence of ischaemic events on Holter monitoring predict hard or soft clinical endpoints in patients with chronic stable angina treated with atenolol, nifedipine SR, or their combination?
Ischaemic events recorded on 48-hour Holter monitoring do not predict hard or soft clinical endpoints in patients with chronic stable angina.
Dargie et al. (1996) studied this question.
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