Why the study?
Does the combination of amlodipine and atenolol improve exercise and ambulatory ischemia parameters compared to either agent alone in patients with stable angina pectoris?
Population
351 patients with stable angina pectoris and ST depression during exercise testing and 48-h ambulatory…
Comparison
Combination of amlodipine and atenolol for 10… vs Amlodipine monotherapy or atenolol monotherapy…
Design
RCT, randomized, triple-arm parallel group, double-blind
Follow-up
10 weeks
Authors
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Supports atenolol monotherapy for stable angina; challenges routine beta-blocker plus calcium-channel blocker combination in guidelines.
Does the combination of amlodipine and atenolol improve exercise and ambulatory ischemia parameters compared to either agent alone in patients with stable angina pectoris?
Combination therapy with a beta-blocker and calcium channel blocker is not necessarily more effective than monotherapy for stable angina.
PEHRSSON et al. (2000) studied this question.
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