Key result
The fixed combination of atenolol and nifedipine significantly improved time to onset of pain (P<0.05) and occurrence of 1 mm ST segment depression (P<0.001) compared to atenolol alone.
Why the study?
Does the fixed combination of atenolol and nifedipine improve exercise tolerance and reduce ischemia compared to atenolol alone in patients with chronic stable angina?
RCT (n=114)
Double-blind
Cross-over
Does the fixed combination of atenolol and nifedipine improve exercise tolerance and reduce ischemia compared to atenolol alone in patients with chronic stable angina?
The fixed combination of atenolol and nifedipine slow release significantly improves exercise tolerance and reduces ischemia compared to atenolol alone in patients with stable angina.
Answers are grounded in this paper and cite their sources.
Favors fixed atenolol-nifedipine over atenolol alone in stable angina; extends RCT evidence for combination anti-ischemic therapy.
One hundred and fourteen patients (94 male) with chronic stable angina who had a positive exercise test after 4 weeks on atenolol alone were randomized to receive either atenolol alone or the fixed combination of atenolol and nifedipine slow release formulation for 4 weeks in a double-blind cross-over manner. Exercise stress testing (Bruce protocol) at the end of each treatment period demonstrated that the time to the onset of pain and occurrence of 1 mm ST segment depression improved significantly (P < 0.05 and P < 0.001 respectively) whilst on the fixed combination compared to atenolol alone. In order to achieve sufficient sensitivity in the analysis of the exercise times, novel statistical methods based on survival analysis were used. Maximum ST segment depression was 0.13 mm less (P < 0.04) while on the fixed combination. The incidence of withdrawals and adverse effects was similar on both treatments.
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R A Foale (1993) conducted an RCT in Chronic stable angina (n=114). Fixed combination of atenolol and nifedipine slow release vs. Atenolol alone was evaluated on Time to onset of pain and occurrence of 1 mm ST segment depression (p=<0.05 and <0.001). The fixed combination of atenolol and nifedipine significantly improved time to onset of pain (P<0.05) and occurrence of 1 mm ST segment depression (P<0.001) compared to atenolol alone.
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