Key result
(Pro)renin receptor mRNA is widely distributed in the anterior and intermediate lobes of the rat pituitary gland, specifically co-expressed in most GH and ACTH cells, and a few prolactin and TSH cells.
The study demonstrates for the first time the distribution of (pro)renin receptor mRNA in specific hormone-producing cells of the rat pituitary gland, suggesting a potential role in modulating pituitary hormone secretion.
Does not inform clinical practice; extends (P)RR localization to specific rat pituitary cells and leaves open any role in hormone secretion.
Expression of (pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, was studied in rat pituitary gland. In situ hybridization showed that cells expressing (P)RR mRNA were widely distributed in the anterior lobe and intermediate lobe of the pituitary gland. Double-staining using in situ hybridization for (P)RR mRNA and immunohistochemistry for the pituitary hormones showed that (P)RR mRNA was expressed in most of the GH cells and ACTH cells in the anterior lobe. (P)RR mRNA was also expressed in a few prolactin cells and TSH cells, but not in LH cells. The present study has shown for the first time the distribution of (P)RR mRNA expressing cells in the rat pituitary gland. These findings suggest that (P)RR plays physiological roles in the pituitary gland, such as the modulation of the pituitary hormone secretion.
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Takahashi et al. (2013) studied this question. (Pro)renin receptor expression was evaluated on Localization of (P)RR mRNA in pituitary cells. (Pro)renin receptor mRNA is widely distributed in the anterior and intermediate lobes of the rat pituitary gland, specifically co-expressed in most GH and ACTH cells, and a few prolactin and TSH cells.
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