The study demonstrates that the 20-kDa light chain suppresses actin-activated ATPase activity in smooth muscle myosin, which is released upon phosphorylation, requiring the presence of two myosin heads.
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S-1-S-2 cleavage activates unphosphorylated myosin ATPase to phosphorylated levels; leaves open its physiological role in vascular smooth muscle regulation.
Hasegawa et al. (1990) studied this question.
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