February 17, 1981Biochemistry

Structural changes in synthetic myosin minifilaments and their dissociation by adenosine triphosphate and pyrophosphate

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Population

Synthetic myosin and rod filaments (minifilaments) prepared in 10 mM Tris-citrate buffer, pH 8.0

Design

Preclinical

Authors

COChristine Oriol-AuditCollège de France JLJames A. LakeIdaho National Laboratory EREmil ReislerUniversity of California, Los Angeles

Discussion

Member takes

Implication

Informs myosin structural responses in animal models; leaves open translation to human cardiac thick filament regulation.

Structured PICO

Population

Synthetic myosin and rod filaments (minifilaments) prepared in 10 mM Tris-citrate buffer, pH 8.0

Intervention

Adenosine triphosphate (ATP) and pyrophosphate

Outcome

Dissociation of minifilaments and structural changes (alpha-helical content measured by circular dichroism)surrogate

Structural changes in myosin induced by ATP and pyrophosphate are localized to the subfragment 2 region, highlighting the role of charge interactions in thick filament function.

Cite This Study

Oriol-Audit et al. (1981) studied this question.

synapsesocial.com/papers/6a8c1921a42d46e0ffcae135 https://doi.org/10.1021/bi00507a002

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Structural changes in synthetic myosin minifilaments and their dissociation by adenosine triphosphate and pyrophosphate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structural changes in synthetic myosin minifilaments and their dissociation by adenosine triphosphate and pyrophosphate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider