Key result
Serum heart-type fatty acid-binding protein (s-HFABP) levels independently predicted the development of true worsening renal failure in acute heart failure (OR 5.472; 95% CI 2.729-10.972; P≤0.001).
Why the study?
True worsening renal failure is linked to poor prognosis in acute heart failure, prompting the need for a biomarker strategy to predict its occurrence.
Does serum heart-type fatty acid-binding protein (s-HFABP) predict true worsening renal failure and long-term outcomes in patients with acute heart failure?
Comparison
Non-WRF vs pseudo-WRF vs true-WRF groups
Design
Observational cohort study
Follow-up
1000 days
Authors
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May identify acute heart failure patients at renal risk on admission; leaves open incremental value over standard predictors.
Observational (n=281)
Does serum heart-type fatty acid-binding protein (s-HFABP) predict true worsening renal failure and long-term outcomes in patients with acute heart failure?
Odds Ratio: 5.472 (95% CI 2.729–10.972)
p-value: p=≤ 0.001
Serum heart-type fatty acid-binding protein (s-HFABP) measured on admission can predict the development of true worsening renal failure and subsequent poor prognosis in patients with acute heart failure.
Shirakabe et al. (2019) conducted an observational in Acute heart failure (n=281). Serum heart-type fatty acid-binding protein (s-HFABP) vs. Lower s-HFABP levels was evaluated on True worsening renal failure (WRF) (OR 5.472, 95% CI 2.729-10.972, p=≤ 0.001). Serum heart-type fatty acid-binding protein (s-HFABP) levels independently predicted the development of true worsening renal failure in acute heart failure (OR 5.472; 95% CI 2.729-10.972; P≤0.001).
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