Key result
The MUSICO multiscale Monte Carlo platform demonstrated large differences in predicted force-velocity curves and early force recovery compared to mass action kinetic models.
A new 3-D stochastic model of actin-myosin binding demonstrates that spatially explicit geometrical constraints significantly alter predicted force-velocity curves compared to traditional mass action kinetic models.
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No immediate clinical implications for cardiac mechanics; challenges mass-action models and leaves open validation of stochastic platforms.
Mijailovich et al. (2016) studied this question. MUSICO multiscale Monte Carlo platform vs. mass action kinetic models was evaluated on force-velocity curves and response during early force recovery phase. The MUSICO multiscale Monte Carlo platform demonstrated large differences in predicted force-velocity curves and early force recovery compared to mass action kinetic models.
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