Alkenylzinc-Mediated Approach to the Vitamin D Skeleton. Application to the Synthesis of 6-Methyl Analogs of Vitamin and Previtamin D

This is the authors' abstract. We don't add key points for this paper.

Palladium-catalyzed cross-coupling of alkenylzinc reagents, bearing the C,D-ring/side chain portion, and ( Z )-1-iodo-1,3-bis-exocyclic dienes (as A-ring precursors), provides a mild, convergent entry to the vitamin D skeleton, that is suitable for the synthesis of thermally labile derivatives such as those bearing substituents on the triene system.