January 28, 1991FEBS Letters

The bulk of Ca2+ released to the myoplasm is free in the sarcoplasmic reticulum and does not unbind from calsequestrin

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Population

Frog skeletal muscle

Design

Preclinical

Authors

PVPompco VolpeThe University of Texas Medical Branch at Galveston BSBruce J. SimonMountain Lakes High School

Discussion

Member takes

Implication

Animal SR Ca2+ data should not change clinical assumptions; leaves open CS buffering role in human cardiac release.

Structured PICO

Population

Frog skeletal muscle

Intervention

Measurement of Ca2+ binding properties and tissue concentration of calsequestrin (CS)

Outcome

Ca2+ binding capacity, apparent Kds for Ca2+, and concentration of CS in homogenatessurrogate

The study demonstrates that the majority of calcium released during a muscle twitch is free in the sarcoplasmic reticulum rather than unbinding from calsequestrin.

Cite This Study

Volpe et al. (1991) studied this question.

synapsesocial.com/papers/6a8c1d451692ae2bc0f47e10 https://doi.org/10.1016/0014-5793(91)80134-o

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The bulk of Ca2+ released to the myoplasm is free in the sarcoplasmic reticulum and does not unbind from calsequestrin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The bulk of Ca2+ released to the myoplasm is free in the sarcoplasmic reticulum and does not unbind from calsequestrin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider