Key result
The swine myocardium is significantly more susceptible to developing ventricular arrhythmias during epicardial ablation compared to the canine model (adjusted OR 3.60; 95% CI 1.35-9.55; P=0.010).
Why the study?
Choosing the appropriate animal model for developing novel technologies requires understanding anatomy and physiology, but little data exist comparing models for studying epicardial ablation technologies.
Does epicardial ablation in swine models increase the incidence of ventricular arrhythmias compared to canine models?
Observational (n=12)
Does epicardial ablation in swine models increase the incidence of ventricular arrhythmias compared to canine models?
Swine myocardium is more susceptible to developing ventricular arrhythmias during epicardial ablation compared to canine models, which is an important consideration for preclinical testing of novel ablation technologies.
Urges caution extrapolating swine ablation data; leaves open optimal species selection for preclinical arrhythmia studies.
BACKGROUND: Choosing the appropriate animal model for development of novel technologies requires an understanding of anatomy and physiology of these different models. There are little data about the characteristics of different animal models for the study of technologies used for epicardial ablation. We aimed to compare the incidence of ventricular arrhythmias during epicardial radiofrequency ablation between swine and canine models using novel epicardial ablation catheters. METHODS: We conducted a retrospective study using data obtained from epicardial ablation experiments performed on swine (Sus Scrofa) and canine (Canis familiaris) models. We compared the incidence of ventricular arrhythmias during ablation between swine and canine using multivariate regression analysis. Six swine and six canine animals underwent successful epicardial radiofrequency ablation. A total of 103 ablation applications were recorded. RESULTS: Ventricular arrhythmias requiring cardioversion occurred in 13.11% of radiofrequency ablation applications in swine and 9.75% in canine (relative risk: 117.6%, 95% confidence interval [CI]: 83.97-164.69, animal-based odds ratio [OR]: .55, 95% CI: .23-61.33; P = .184). When adjusting for application position, duration of ablation and power, the odds of developing potentially lethal ventricular arrhythmia in swine increased significantly compared to canine (OR: 3.60, 95% CI: 1.35-9.55; P = .010). CONCLUSIONS: The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.
No takes yet. Share an insight, caveat, or question.
Caluori et al. (2019) conducted an observational in Ventricular arrhythmias during epicardial ablation (n=12). Swine model vs. Canine model was evaluated on Ventricular arrhythmias requiring cardioversion (OR 3.60, 95% CI 1.35-9.55, p=.010). The swine myocardium is significantly more susceptible to developing ventricular arrhythmias during epicardial ablation compared to the canine model (adjusted OR 3.60; 95% CI 1.35-9.55; P=0.010).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: