Key result
Local transfer of the VEGF gene resulted in more prominent neointima formation, whereas treatment with L-arginine was associated with significantly less intimal thickness (p < 0.05).
Why the study?
Does local gene transfer of VEGF and/or L-arginine reduce neointima formation after balloon injury in hypercholesterolemic rabbits?
Population
34 New Zealand White male rabbits weighing 2.75-3.25 kg undergoing balloon injury of the iliac arteries.
Comparison
Local delivery via Dispatch catheter of… vs Comparisons among the 4 local delivery treatment…
Design
Preclinical, Measurements of intimal and medial cross-sectional area were…
Follow-up
28 days for hypercholesterolemic rabbits, 3 days for…
Authors
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May caution against VEGF gene transfer in atherosclerotic vessels; leaves open L-arginine's role pending human trials.
Does local gene transfer of VEGF and/or L-arginine reduce neointima formation after balloon injury in hypercholesterolemic rabbits?
p-value: p=<0.05
Local VEGF gene transfer does not inhibit neointima formation in hypercholesterolemic rabbits after balloon injury, suggesting it may not be beneficial in atherosclerotic arteries, whereas L-arginine reduces intimal thickness.
Dulak et al. (2005) studied Neointima formation after balloon injury in hypercholesterolemia (n=34). Local gene transfer of VEGF (pSG5VEGF165 plasmid) vs. L-arginine alone or with control plasmid was evaluated on Neointima formation (intima/media ratio) (p=<0.05). Local transfer of the VEGF gene resulted in more prominent neointima formation, whereas treatment with L-arginine was associated with significantly less intimal thickness (p < 0.05).
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