Interaction Between Nalidixic Acid and Warfarin

Letters and Corrections1 October 1987Interaction Between Nalidixic Acid and WarfarinJONATHAN LEOR, M.D., DAVID LEVARTOWSKY, M.D., CHARLOTTE SHARON, M.D.JONATHAN LEOR, M.D., DAVID LEVARTOWSKY, M.D., CHARLOTTE SHARON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-4-601_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nalidixic acid, the prototype of the quinolones family, is used extensively as an antimicrobial agent for urinary tract infections. The following case report suggests that nalidixic acid given to patients on long-term warfarin therapy can cause potentially dangerous over-anticoagulation. It is important to report this interaction due to the recent introduction of the new fluroquinolone agents structurally related to nalidixic acid.A 71-year-old woman with mitral stenosis, chronic atrial fibrillation, and thromboembolic phenomena, began warfarin treatment 6 years ago. Her regular dose was between 2.5 to 5 mg/d. The prothrombin time was well controlled within the acceptable...References1. HOFFBRAND B. Interaction of nalidixic acid and warfarin [Letter]. Br Med J. 1974;2:666. CrossrefMedlineGoogle Scholar2. POTASMANBASSAN IH. Nicoumalone and nalidixic acid interaction [Letter]. Ann Intern Med. 1980;92:571. LinkGoogle Scholar3. SELLERKOCH-WESER EJ. Displacement of warfarin from human albumin by diazoxide and ethacrynic mefenamic, and nalidixic acids. Clin Pharmacol Ther. 1970;11:524-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JONATHAN LEOR, M.D.; DAVID LEVARTOWSKY, M.D.; CHARLOTTE SHARON, M.D.Affiliations: Tel-Aviv University Tel-Hashomer, Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCoumarin anticoagulantsANTICOAGULANTS, THROMBOLYTIC AGENTS, AND ANTI-PLATELET DRUGSCoumarin anticoagulantsThe safety of levofloxacin in elderly patients on warfarinMoxifloxacin—Warfarin Interaction: A Series of Five Case ReportsLevofloxacin and Warfarin InteractionINTERACTIONS OF WARFARINDrug Interactions with Antimicrobial AgentsEffect of ciprofloxacin on the hypoprothrombinemic activity of warfarin in ratsReaders' ForumCiprofloxacin interaction with sodium warfarin: A potentially dangerous side effectFluoroquinolone-drug interactions: An overviewDrug-drug interactions with ciprofloxacin and other fluoroquinolonesNorfloxacin and WarfarinTerry Linville, MD, Dean Matanin, PharmDOfloxacin and WarfarinJonathan Leor, MD, Shlomo Matetzki, MDDrug Interactions and Adverse Reactions 1 October 1987Volume 107, Issue 4Page: 601-601KeywordsAntimicrobialsAtrial fibrillationMitral stenosisProthrombin time ePublished: 1 December 2008 Issue Published: 1 October 1987 PDF downloadLoading ...