What question did this study set out to answer?

To determine taurine concentrations in brain and liver tissues across prenatal and postnatal developmental stages in humans and Rhesus monkeys.

December 1, 1975Journal of Neurochemistry

Taurine in the Brain and Liver of the Developing Human and Monkey

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To determine taurine concentrations in brain and liver tissues across prenatal and postnatal developmental stages in humans and Rhesus monkeys.
Measured taurine concentrations in liver and brain tissues from second-trimester human fetuses and human adults.
Quantified taurine in Rhesus monkeys from mid-gestation, through birth and neonatal life, to maturity.
Evaluated correlations between tissue taurine levels and developmental indicators, including crown-rump length and postnatal age.
Taurine concentrations in fetal human and monkey brains were 4- to 5-fold higher than in adult monkey brains.
Human fetal brain taurine declined linearly with crown-rump length (r = -0.75, P < 0.001), while postnatal monkey brain taurine decreased linearly with age (r = -0.96, P < 0.001) until reaching adult values at 8-9 months.
Fetal liver taurine was roughly twice adult concentrations in both species, but reached adult levels within days of birth compared to several months in the brain.

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Implication

Comparative developmental analysis demonstrates elevated taurine levels in fetal and neonatal humans and monkeys, suggesting an essential role in early brain maturation.

Cite This Study

Sturman et al. (1975) studied this question.

synapsesocial.com/papers/6a8c25c9de5ec4e001e3ec28 https://doi.org/10.1111/j.1471-4159.1975.tb04414.x

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Implication

Comparative developmental analysis demonstrates elevated taurine levels in fetal and neonatal humans and monkeys, suggesting an essential role in early brain maturation.

Taurine in the Brain and Liver of the Developing Human and Monkey

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Discussion

Implication

Cite This Study

Taurine in the Brain and Liver of the Developing Human and Monkey

Key Points

Discussion

Implication

Cite This Study

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