Key result
Obesity was independently associated with a significantly increased risk of 30-day mortality in patients with acute respiratory distress syndrome compared to normal weight (adjusted HR 3.85).
Why the study?
The study was conducted to evaluate the link between obesity and mortality in patients with acute respiratory distress syndrome.
Does obesity impact short- and long-term mortality in patients with acute respiratory distress syndrome?
Cohort (n=418)
No
Does obesity impact short- and long-term mortality in patients with acute respiratory distress syndrome?
In patients with ARDS, there is a U-shaped relationship between BMI and mortality, with obesity independently associated with a significantly increased risk of short- and long-term death.
Answers are grounded in this paper and cite their sources.
Obesity may increase ARDS mortality risk; this Level 3 cohort study leaves open causal mechanisms and prospective trials.
Objective To evaluate the link between obesity and mortality in patients with acute respiratory distress syndrome (ARDS). Methods We performed a retrospective cohort study of a large clinical database. A Cox proportional hazards regression model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the relationship between body mass index (BMI) and mortality. The primary endpoint was 30-day death rate and the secondary endpoints were 90-day and 1‑year mortality. Results Overall, 418 patients with ARDS were enrolled in the study, including 185 women and 233 men (age: 70.7 ± 44.1 years; BMI: 28.7 ± 8.1 kg/m2). Compared with patients with normal weight, obese patients were younger (60.1 ± 13.7, p = 0.003) and a higher percentage of these patients were women (51.3% vs. 49.0%, p = 0.001). The HRs (95% CI) of 30-day mortality in the underweight, overweight, and obese populations were 1.82 (0.85, 3.90), 0.59 (0.29, 1.20), and 3.85 (1.73, 8.57), respectively, after adjustment for other confounding factors. A similar pattern was also seen for death after 90 days and after 1 year. A U-shaped association between BMI and 30-day mortality was discovered by curve fitting. Conclusion Obesity had a significant impact on the short- and long-term mortality in patients with ARDS. There was a U-shaped relationship between BMI and mortality, while a higher BMI was associated with an increased risk of death in patients with ARDS.
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Qiyan Lou (2023) conducted a cohort in Acute respiratory distress syndrome (ARDS) (n=418). Obesity (BMI >30 kg/m2) vs. Normal weight (BMI 18.5-25 kg/m2) was evaluated on 30-day mortality (HR 3.85, 95% CI 1.73-8.57, p=0.0019). Obesity was independently associated with a significantly increased risk of 30-day mortality in patients with acute respiratory distress syndrome compared to normal weight (adjusted HR 3.85).
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