Selective COX-2 inhibitors may offer effective perioperative analgesia with reduced adverse effects compared to traditional NSAIDs, though their clinical utility requires further determination.
Should not yet alter perioperative NSAID use; leaves open definitive efficacy and safety trials for selective COX-2 inhibitors.
Non-steroidal anti-inflammatory drugs are widely used for perioperative analgesia as a sole analgesic after minor surgical procedures and in combination with other types of analgesics after major surgery. The development and use of new selective cyclo-oxygenase-2 inhibitors hopefully reduce the likelihood of perioperative adverse effects that may prevent the use of non-steroidal anti-inflammatory analgesics in many patients. It remains to be determined, however, whether they can offer effective analgesia with minimal risks of side-effects in everyday clinical use.
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Tarkkila et al. (1998) studied this question.
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