Why the study?
Does colostrum influence antibody response to non-living antigens in baby pigs?
Does colostrum influence antibody response to non-living antigens in baby pigs?
Colostrum is essential for the development of active antibody responses to non-living antigens in baby pigs, though immune colostrum can interfere with active production.
Hypothesis-generating in neonatal pigs; leaves open translation to human infant immunization and vaccine timing.
Summary Comparisons have been made between the antibody response to non-living antigens in baby pigs deprived of colostrum, baby pigs receiving normal (“non-immune”) colostrum and pigs receiving “immune” colostrum. Baby pigs under 8 weeks of age deprived of colostrum did not produce a measurable serologic response to the antigens used. Baby pigs that received normal (“non-immune”) colostrum responded to antigens when inoculated at 3 weeks of age. This response increased markedly to 6 weeks of age. Passive transfer of antibodies through “immune” colostrum interfered with active antibody production between 3 and 6 weeks of age. The inoculation of ovine RBC produced a response which differed in some respects from the antigen-antibody reactions studied. Part of this appears to be associated with intrauterine sensitization to this complex antigen. Anaphylactic shock resulted from both active and passive (effected through “immune” colostrum) sensitization.
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Alvin B. Hoerlein (1957) studied this question.
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