Key result
In vivo chemical screening in zebrafish is an effective model for both drug discovery and structure-activity relationship optimization.
Zebrafish provide a rapid and efficient in vivo model for drug discovery, allowing early determination of bioactivity, toxicity, and structure-activity relationships.
In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.
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Bowman et al. (2010) reported a review. In vivo chemical screening in zebrafish was evaluated. In vivo chemical screening in zebrafish is an effective model for both drug discovery and structure-activity relationship optimization.
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