Population
Rabbit and rat isolated vascular smooth muscle preparations (aortic rings, renal artery, basilar artery)
Comparison
KT3-671 vs Control conditions and other antagonists
Design
Preclinical
Authors
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Hypothesis-generating for K(ATP)-mediated AT1 antagonism; requires in vivo and clinical validation before therapeutic consideration.
KT3-671 acts as an insurmountable antagonist of Angiotensin II in rabbit and rat vascular smooth muscle, potentially involving K(ATP) channels.
Satake et al. (2000) studied this question.
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