No evidence of type 1 or type 3 hypersensitivity mechanism in amoxicillin/clavulanic acid induced aseptic meningitis

Drug induced aseptic meningitis has been reported in response to various agents, in particular non-steroidal anti-inflammatory drugs, intravenous immunoglobulins, anti-CD3 monoclonal antibody (OKT3), and antibiotics.1 Hypersensitivity reactions (especially type 1 and type 3) have been invoked as the cause by many investigators.1 This hypothesis is supported by the detection of immune complexes in the serum or cerebrospinal fluid (CSF) of some patients.1 To our knowledge, only two cases of aseptic meningitis induced by amoxicillin with or without clavulanic acid have been reported.2,3 We report a third case of probable amoxicillin induced aseptic meningitis where we performed laboratory studies …