Key result
The Pro12Ala polymorphism of the PPARG gene was not significantly associated with diabetic nephropathy overall (Pro/Pro OR 1.42; 95% CI 0.96-2.09), but the Pro/Pro genotype increased risk in Asians.
Why the study?
Is the Pro12Ala polymorphism in the PPARG gene associated with susceptibility to diabetic nephropathy?
Meta-Analysis (n=2,758)
Is the Pro12Ala polymorphism in the PPARG gene associated with susceptibility to diabetic nephropathy?
Answers are grounded in this paper and cite their sources.
The Pro12Ala polymorphism of the PPARG gene may be associated with an increased risk of diabetic nephropathy specifically among Asian populations.
BACKGROUND: The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma (PPARG) gene is suggested to associate with diabetic nephropathy. AIM: A meta-analysis was conducted to investigate the potential association of PPARG gene polymorphisms with susceptibility to diabetic nephropathy. METHODS: A comprehensive search of MEDLINE (1966 to June 2011) was conducted to identify published epidemiologic studies related to polymorphisms of the PPARG gene and diabetic nephropathy. A database search yielded 5 studies involving 2758 patients. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. RESULTS: The combined results based on all studies showed no significant difference in genotype distribution (Pro/Pro: OR. 1.42, 95% CI, 0.96-2.09); Pro/Ala: OR, 0.74, 95% CI, 0.50-1.10; Ala/Ala: OR, 0.85, 95% CI, 0.52-1.38) between cases and controls. After stratification for race, results were similar except that patients with diabetic nephropathy had a significantly higher frequency of Pro/Pro (OR, 1.82; 95% CI, 1.17-2.85) than controls among Asians. CONCLUSION: This meta-analysis suggests that the Pro12Ala polymorphism of the PPARG gene may be associated with diabetic nephropathy among Asians.
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Yu et al. (2011) conducted a meta-analysis in diabetic nephropathy (n=2,758). Pro12Ala polymorphism in the PPARG gene vs. controls was evaluated on diabetic nephropathy (OR 1.42, 95% CI 0.96-2.09). The Pro12Ala polymorphism of the PPARG gene was not significantly associated with diabetic nephropathy overall (Pro/Pro OR 1.42; 95% CI 0.96-2.09), but the Pro/Pro genotype increased risk in Asians.
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