Key result
The CD143 rs4340 polymorphism D/D genotype was associated with a significantly increased risk of pneumonia compared to other genotypes (OR 1.33).
Why the study?
Is the CD143 rs4340 polymorphism associated with an increased risk of pneumonia?
Meta-Analysis (n=3,941)
Is the CD143 rs4340 polymorphism associated with an increased risk of pneumonia?
The CD143 rs4340 polymorphism is associated with an increased risk of pneumonia, including both community-acquired and nosocomial pneumonia.
Answers are grounded in this paper and cite their sources.
Does not support CD143 genotyping in practice; extends observational genetic evidence but remains hypothesis-generating.
rs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia. There have been different reports regarding the correlation of CD143 rs4340 genotypes with pneumonia risk, which prompted us to perform a meta-analysis to determine the elusive association.We combined multiple keywords to identify the studies addressing the association between CD143 rs4340 genotypes and pneumonia risk covered in the EMBASE, Google Scholar, PubMed, and CNKI databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the risk of pneumonia. The fixed-effects model (FEM) was used.A total of 10 studies were analyzed in this quantitative analysis. We found a strong association between rs4340 single nucleotide polymorphism (SNP) and pneumonia risk using the recessive model (FEM: OR 1.33, 95% CI 1.13-1.57). A significantly increased risk was also indicated under the recessive model in Asian populations (FEM: OR 1.57, 95% CI 1.19-2.07), community-acquired pneumonia (CAP) (FEM: OR 1.31, 95% CI 1.08-1.60), and nosocomial pneumonia (NP) (FEM: OR 1.52, 95% CI 1.06-2.19).Our meta-analysis demonstrates that CD143 rs4340 polymorphism may represent a risk factor for pneumonia.
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Wang et al. (2015) conducted a meta-analysis in Pneumonia (n=3,941). CD143 rs4340 polymorphism (D/D genotype) vs. I/D + I/I genotypes was evaluated on Pneumonia risk (recessive model) (OR 1.33, 95% CI 1.13-1.57). The CD143 rs4340 polymorphism D/D genotype was associated with a significantly increased risk of pneumonia compared to other genotypes (OR 1.33).
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