Key result
ACE I/D polymorphism was significantly associated with increased pneumonia risk in a recessive genetic model (OR 1.53; 95% CI 1.30-1.80; p<0.00001), but not with pneumonia-related mortality.
Why the study?
Is the ACE I/D polymorphism associated with increased pneumonia risk and pneumonia-related mortality?
Meta-Analysis (n=5,031)
Is the ACE I/D polymorphism associated with increased pneumonia risk and pneumonia-related mortality?
The ACE I/D polymorphism is significantly associated with an increased risk of developing pneumonia, though it does not appear to affect pneumonia-related mortality.
May inform genetic susceptibility screening for pneumonia; leaves open prospective validation and any role in risk stratification.
BACKGROUND: Previous studies examined the association between angiotensin-converting enzyme (ACE) I/D polymorphism and pneumonia, but their results were inconsistent. Thus, a meta-analysis was performed to clarify the effect of ACE I/D polymorphism on pneumonia risk and pneumonia-related mortality. METHODS: The PubMed, Embase, and Chinese National Knowledge Infrastructure (CNKI) databases were searched for relevant studies published up to 27 April 2013. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. RESULTS: Pooled analysis of 12 case-control studies (1431 cases and 3600 controls) showed that there was a significant association between ACE I/D polymorphism and pneumonia risk in a recessive genetic model (OR = 1.53, 95% CI 1.30-1.80, p < 0.00001). No significant association between ACE I/D polymorphism and mortality was observed (OR = 2.68, 95% CI 0.80-8.90, p = 0.11). CONCLUSIONS: Our meta-analysis confirmed that ACE I/D polymorphism was associated with pneumonia risk. However, ACE I/D polymorphism was not associated with pneumonia mortality.
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Nie et al. (2014) conducted a meta-analysis in Pneumonia (n=5,031). ACE I/D polymorphism was evaluated on Pneumonia risk in a recessive genetic model (OR 1.53, 95% CI 1.30-1.80, p=< 0.00001). ACE I/D polymorphism was significantly associated with increased pneumonia risk in a recessive genetic model (OR 1.53; 95% CI 1.30-1.80; p<0.00001), but not with pneumonia-related mortality.
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