Key result
ACE I/D polymorphism linked to ~25% lower sepsis risk in a recessive genetic model.
Why the study?
Previous studies investigating the association between the angiotensin-converting enzyme I/D polymorphism and sepsis have provided inconsistent results.
Is the angiotensin-converting enzyme I/D polymorphism associated with sepsis risk and mortality?
Meta-Analysis
Is the angiotensin-converting enzyme I/D polymorphism associated with sepsis risk and mortality?
Odds Ratio: 0.75 (95% CI 0.62–0.91)
p-value: p=0.004
The ACE I/D polymorphism is associated with an altered risk of developing sepsis, but does not appear to impact sepsis-related mortality.
May support further genetic studies in sepsis; leaves open clinical relevance of ACE I/D polymorphism.
BACKGROUND: Previous studies investigating the association between the angiotensin-converting enzyme I/D polymorphism and sepsis have provided inconsistent results. Thus, a meta-analysis was performed to clarify the effect of the angiotensin-converting enzyme I/D polymorphism on sepsis risk and sepsis-related mortality. METHODS: A comprehensive literature search was performed. Six case-control studies and two cohort studies were included in this meta-analysis. Odds ratios and corresponding 95% confidence intervals were estimated using random-effects models. RESULTS: Pooled analysis of six case-control studies showed that there was a significant association between the angiotensin-converting enzyme I/D polymorphism and sepsis risk in a recessive genetic model (odds ratio = 0.75, 95% confidence interval 0.62-0.91, p = 0.004). However, no significant association between the angiotensin-converting enzyme I/D polymorphism and mortality was observed (odds ratio = 0.84, 95% confidence interval 0.57-1.24, p = 0.38). CONCLUSIONS: Our meta-analysis confirmed that the angiotensin-converting enzyme I/D polymorphism was associated with sepsis risk. However, the angiotensin-converting enzyme I/D polymorphism was not associated with sepsis mortality.
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Hou et al. (2013) conducted a meta-analysis in Sepsis. Angiotensin-converting enzyme I/D polymorphism was evaluated on Sepsis risk (OR 0.75, 95% CI 0.62-0.91, p=0.004). The angiotensin-converting enzyme I/D polymorphism was significantly associated with a reduced risk of sepsis in a recessive genetic model (OR 0.75; 95% CI 0.62-0.91; p=0.004).
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