June 1, 1993Endocrinology

Co-expression of type 1 angiotensin II receptor (AT1R) and renin mRNAs in juxtaglomerular cells of the rat kidney.

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Population

Rat kidney cells

Design

Preclinical

Authors

JGJean‐Marie GascInserm CMCatherine MonnotInserm ÉCÉric ClauserGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Does not inform clinical RAAS management; extends molecular evidence for direct Ang II feedback in rodent JG cells.

Structured PICO

Population

Rat kidney cells

Intervention

In situ hybridization using AT1R cDNA and renin cRNA probes

Outcome

Localization of AT1R mRNA expression and co-expression with renin mRNAsurrogate

Demonstrates co-expression of AT1R and renin mRNAs in rat kidney juxtaglomerular cells, providing visual evidence for direct feedback control of Angiotensin II on renin secretion.

Cite This Study

Gasc et al. (1993) studied this question.

synapsesocial.com/papers/6a8c38297239707559bef05b https://doi.org/10.1210/endo.132.6.8504772

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Co-expression of type 1 angiotensin II receptor (AT1R) and renin mRNAs in juxtaglomerular cells of the rat kidney.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Co-expression of type 1 angiotensin II receptor (AT1R) and renin mRNAs in juxtaglomerular cells of the rat kidney.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider