Effects of Thoracic Epidural Anesthesia with and without Autonomic Nervous System Blockade on Cardiac Monophasic Action Potentials and Effective Refractoriness in Awake Dogs
Why the study?
Does thoracic epidural anesthesia affect myocardial repolarization and effective refractoriness in awake dogs?
Population
Awake dogs (in vivo canine model)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for antiarrhythmic effects at short cycle lengths in dogs; leaves open translation to human electrophysiology.
Structured PICO
Does thoracic epidural anesthesia affect myocardial repolarization and effective refractoriness in awake dogs?
P
Population
Awake dogs (in vivo canine model)
I
Intervention
Thoracic epidural anesthesia (TEA) with and without autonomic nervous system blockade
O
Outcome
Right atrial and ventricular repolarization (monophasic action potential duration and effective refractory period)surrogate
Thoracic epidural anesthesia prolongs ventricular repolarization and refractoriness at short cycle lengths in awake dogs, suggesting a potential antiarrhythmic effect.
Cite This Study
Meißner et al. (2001) studied this question.