Why the study?
Does thoracic epidural analgesia have additional cardiac electrophysiological and hemodynamic effects when induced after beta-adrenergic blockade in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Thoracic epidural analgesia with bupivacaine… vs Intravenous injection of atenolol alone
Design
Preclinical
Authors
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May additively depress nodal function and LV inotropy beyond beta-blockade in dogs; leaves open translation to human perioperative use.
Does thoracic epidural analgesia have additional cardiac electrophysiological and hemodynamic effects when induced after beta-adrenergic blockade in anesthetized dogs?
Thoracic epidural analgesia has additive depressive effects on sinoatrial and AV nodal functions and left ventricular inotropy when induced after beta-blockade in dogs.
Hotvedt et al. (1984) studied this question.
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