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To resolve the paradox of Cbl functioning as both an oncogene and a tumor suppressor in the pathogenesis of human myeloid neoplasms.

May 26, 2010Cancer ResearchOpen Access

Cbl and Human Myeloid Neoplasms: The Cbl Oncogene Comes of Age

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To resolve the paradox of Cbl functioning as both an oncogene and a tumor suppressor in the pathogenesis of human myeloid neoplasms.
Evaluation of biochemical and molecular studies characterizing Cbl as a RING finger ubiquitin ligase and signaling adaptor protein.
Synthesis of published genomic data identifying homozygous Cbl mutations in human myeloid malignancies.
Homozygous mutations in Cbl selectively abrogate ubiquitin ligase activity while maintaining adaptor-mediated positive signaling.
Loss of negative regulation coupled with sustained pathway activation reconciles the dual oncogenic and tumor suppressor functions of Cbl, providing a foundation for targeted interventions.

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Review reveals dual oncogenic and tumor suppressor mechanisms of mutant Cbl in human myeloid neoplasms, suggesting novel therapeutic strategies.

Kales et al. (2010) studied this question.

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Review reveals dual oncogenic and tumor suppressor mechanisms of mutant Cbl in human myeloid neoplasms, suggesting novel therapeutic strategies.