Association of VEGF protein expression according to muscle fiber types with diet and exercise intervention in diet-induced obese rats

Association of vascular endothelial growth factor protein expression according to muscle fiber types with diet and exercise intervention in diet-induced obese rats.Exercise Science, 22(1): 85-94.2013.This study measured vascular endothelial growth factor (VEGF) protein expression of different skeletal muscle fiber types after a 6-week intervention of energy restriction and exercise in diet-induced obese rats.The changes in protein expression were analyzed across the different 6-weeks intervention programs of diet, exercise, and diet plus exercise.After intake of high fat diet for 6-weeks, obesity-induced groups showed a significantly higher body weight as compared to control group.The diet plus exercise (B) group showed a significantly lower visceral fat volume after 6-weeks, and obese group showed a higher visceral fat volume than the other groups.Diet alone group, and diet plus exercise (B) group showed a significantly higher VEGF protein expression in red gastrocnemius muscle after 6-weeks of treatment as compared to the pre-level of control group.The diet alone group, exercise group, and diet plus exercise (B) groups showed a significantly higher VEGF protein expression in white gastrocnemius muscle after 6-weeks of treatment as compared to the pre-level of obese group, but these groups showed no significant differences as compared to the pre-level of control group.The exercise group showed a significantly higher VEGF protein expression in soleus muscle after 6-weeks of treatment as compared to the pre-level of the control group, and the exercise group and diet group showed a significantly higher VEGF protein expression in soleus muscle after 6-weeks of treatment as compared to the post-level of the control group.In conclusion, VEGF protein expression of type IIb fibers in gastrocnemius white muscle showed a significant activation after exercise.Key words：Vascular endothelial growth factor (VEGF), Obesity, Diet, Exercise 초 록 홍창배, 천우광, 김기진.비만 흰쥐의 6주간 식이와 운동 처치후 골격근 유형별 VEGF 단백질 발현의 변화.운동과학, 제22 권 제1호, 85-94, 2013.본 연구는 고지방 식이를 이용하여 비만을 유도한 비만 휜쥐를 대상으로 6주간의 식이제한, 운동요법, 식이제한과 운동요법을 병행하여 비만처치를 적용하여 골격근 섬유의 특성에 따른 VEGF 단백질의 발현 양상을 비교한 결과 다음과 같은 결론을 얻었다.체중의 변화를 살펴본