Why the study?
Preclinical data showed celecoxib reduced aortic valve calcification, but retrospective clinical analyses linked celecoxib use with aortic stenosis, leaving the role of COX-2 in calcific aortic valve disease unclear.
Does COX-2 inhibition with celecoxib promote calcification in human aortic valve interstitial cells?
Does COX-2 inhibition with celecoxib promote calcification in human aortic valve interstitial cells?
Reduced COX-2 expression is characteristic of calcific human aortic valves, and COX-2 inhibition with celecoxib promotes pro-calcific processes in vitro, suggesting celecoxib may facilitate CAVD progression.
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COX-2 downregulation may promote aortic valve calcification; hypothesis-generating observation leaves open any role for COX-2 inhibition in CAVD.
Sega et al. (2020) studied this question.
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