Why the study?
Obesity and a high-fat diet are prevalent causes of oxidative stress, but the long-term impact of bariatric surgery and an HF diet on oxidative stress markers in erythrocytes and heart muscles remained unclear.
Does DJOS bariatric surgery compared to SHAM surgery alter oxidative stress markers in the erythrocytes and heart muscle of obese rats on different diets?
Does DJOS bariatric surgery compared to SHAM surgery alter oxidative stress markers in the erythrocytes and heart muscle of obese rats on different diets?
In an obese rat model, dietary patterns (high-fat vs control) exerted a more significant influence on oxidative stress markers in erythrocytes and heart muscle than DJOS bariatric surgery.
Dietary effects may outweigh DJOS surgery on oxidative stress in obese models; leaves open human translation and clinical relevance.
Obesity and high-fat diet (HF) are prevalent causes of oxidative stress (OS). Duodenal-jejunal omega switch (DJOS) is a bariatric procedure used for body mass reduction, extensively tested in animal models. We studied the long-term impact of bariatric surgery and an HF diet on the oxidative stress markers in erythrocytes and heart muscles of rats. We analyzed superoxide dismutase (SOD), catalase (CAT), glutathione transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) activity and malondialdehyde (MDA) concentration in DJOS or SHAM (control) operated rats fed with different dietary protocols (control diet (CD) and high-fat diet (HF)), before and after the surgery (CD/CD, HF/HF, CD/HF, and HF/CD). We observed higher erythrocytes CAT, GST and GPx activity in DJOS-operated (vs. SHAM) rats fed with an HF/HF diet. For DJOS-operated rats, erythrocytes CAT and GPx activity and MDA concentration were significantly lower in CD/CD group. We observed increased heart muscle GR activity in SHAM-operated rats (vs. DJOS bariatric surgery) fed with an HF/HF diet. Change from HF to CD diet increased heart muscle GPx activity after DJOS bariatric surgery. Heart muscle SOD activity was lower in HF/HF and CD/CD groups after DJOS bariatric surgery (vs. SHAM). DJOS surgery significantly reduced heart muscle MDA concentration in HF/HF and HF/CD groups (vs. SHAM). We conclude that the selected dietary patterns had a stronger impact on oxidative stress markers in erythrocytes and heart muscle than DJOS bariatric surgery.
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Skrzep-Poloczek et al. (2020) studied this question.
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