Key result
Laparoscopic sleeve gastrectomy is linked to progressive 1-year improvements in antioxidant defense and oxidative stress.
Why the study?
Oxidative stress plays an important role in the pathogenesis of obesity and its complications, but systemic oxidative stress status and its modulation after bariatric surgery in morbid obese patients are not fully characterized.
Does laparoscopic sleeve gastrectomy improve oxidative stress and metabolic profiles in morbidly obese patients?
Observational
Does laparoscopic sleeve gastrectomy improve oxidative stress and metabolic profiles in morbidly obese patients?
Laparoscopic sleeve gastrectomy significantly improves oxidative stress and metabolic profiles in morbidly obese patients, with urinary 8-oxo-dG serving as a potential marker for monitoring.
LSG was associated with reduced oxidative stress in obese patients; hypothesis-generating and requires randomized confirmation before practice change.
Obesity has grown worldwide over the last few decades. In its different degrees, obesity is accompanied by many clinical and biochemical alterations reflecting the pathological condition of various body tissues. Among the mechanisms underlying the pathogenesis of obesity and associated complications, oxidative stress (OS) may be playing an important role. In the present study, we have characterized at systemic level the degree of OS status in a group of morbid obese patients (BMI>40 kg/m2) at basal sate and its modulation during one year after bariatric surgery using the laparoscopic sleeve gastrectomy (LSG) technique. As compared with normal weight subjects matched in age, peripheral blood mononuclear cells (PBMc) of obese patients present a significant reduction of the antioxidant enzyme activities superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) as well as a significant increase of the oxidized/reduced glutathione ratio (GSSG/GSH) in these cells. Lipid peroxidation is significantly increased in the patient group as shown by the increased levels of malondialdehyde (MDA) in PBMc and the amount of F2-Isoprostanes (F2-IsoPs) released in urine. In addition, the DNA damage product 8-oxo-7,8-2′-deoxyguanosine (8-oxo-dG) was also observed to be increased in serum and urine of morbid obese patients as compared with the control group. After LSG, an improvement of their ponderal and metabolic profile was accompanied by a progressive recovery of antioxidant enzyme activities and the decline of oxidative byproducts both in PBMc and biological fluids. The observed changes of urinary 8-oxo-dG levels correlate positively with its serum concentration, the lipid peroxidation products MDA and F2-IsoPs, triglycerides, glucose, insulin, HOMA index and body weight and negatively with the percentage of weight and BMI loss and antioxidant activities. We conclude that the analysis of urinary 8-oxo-dG could be validated as a useful marker for the monitoring of ponderal and metabolic status of morbid obese patients.
No takes yet. Share an insight, caveat, or question.
Monzó-Beltrán et al. (2017) conducted an observational in Morbid obesity. Laparoscopic sleeve gastrectomy (LSG) vs. Basal state (pre-surgery) and normal weight subjects was evaluated on Oxidative stress status (antioxidant enzyme activities, lipid peroxidation, and 8-oxo-dG levels). Laparoscopic sleeve gastrectomy in morbidly obese patients was associated with a progressive recovery of antioxidant enzyme activities and a decline in oxidative byproducts over one year.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: