Why the study?
Cancer survivors face an increased risk of cardiovascular disease, creating an urgent need for further study on the prevention of cardiovascular toxicity.
Imperatorin is a natural coumarin that may offer protective effects against cardiovascular toxicity in cancer patients, highlighting a potential therapeutic target in cardio-oncology.
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Imperatorin merits targeted cardio-oncology investigation; leaves open any clinical role pending randomized trials.
Patients with cancer survivors are at increased risk of cardiovascular disease(CVD). Cardio-oncology has developed as a new discipline with the advances in cancer treatment. There are many new challenges for the clinician and a new frontier for research and investigation. There is an urgent need for further study on the prevention of cardiovascular toxicity. Imperatorin (IMP) is a natural form of coumarin and extract from several plants with diver's pharmacokinetic effects, including antioxidant and anti-inflammatory properties. This review focus on the molecular mechanisms and pharmacological effects of Imperatorin maybe provide potential cancer and cardiovascular protection that targets IMP. Further studies are required to elucidate the entire spectrum of cytotoxic activities of these compounds to validate and expand their preclinical and clinical applications and to clarify the potential role of IMP.
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Nasser et al. (2019) studied this question.
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