Focal Glomerular Lesions in Fungal Endocarditis

Case Reports1 April 1962Focal Glomerular Lesions in Fungal EndocarditisWILLIAM C. ROBERTS, M.D., ALAN S. RABSON, M.D.WILLIAM C. ROBERTS, M.D.Search for more papers by this author, ALAN S. RABSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-610 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFocal areas of necrosis and sclerosis have frequently been seen in the renal glomeruli of autopsied patients with subacute endocarditis due to bacteria. These glomerular lesions have been called "focal embolic (endocarditic) glomerulonephritis," with the implication that they were the result of multiple small emboli, which were dislodged from cardiac vegetations and landed in the glomerular capillaries. Allen (1) summarized the reasons for rejecting the embolic theory of the pathogenesis of these lesions and agreed with Longcope (2) who considered these lesions to be of an allergic nature. Since fungal infections in man are commonly associated with manifestations of hypersensitivity...References1. ALLEN AC: The Kidney, Medical and Surgical Diseases. Grune & Stratton, Inc., New York, 1951, pp. 164-170. Google Scholar2. LONGCOPE WT: The susceptibility of man to foreign proteins. Amer. J. Med. Sci. 152: 625, 1916. CrossrefGoogle Scholar3. ANDRIOLEKRAVETZROBERTSUTZ VTHMWCJP: Candida endocarditis: clinical and pathological studies. Amer. J. Med. 32: 251, 1962. CrossrefMedlineGoogle Scholar4. PASTERNACK JG: Subacute monilia endocarditis: new clinical and pathological entity. Amer. J. Clin. Path. 12: 496, 1942. CrossrefGoogle Scholar5. NIEL K: Zur Klinik der Candidainfektionen. Klin. Med. (Wien) 8: 49, 1953. Google Scholar6. KOHLMEIER W: Zur Kenntnis der Candidainfektionen. Klin. Med. 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MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Pathologic Anatomy Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.Requests for reprints should be addressed to William C. Roberts, M.D., Pathologic Anatomy Department, Clinical Center, National Institutes of Health, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEndocardites à Candida : étude rétrospective de 12 patientsComparison of active infective endocarditis involving a previously stenotic versus a previously nonstenotic aortic valveCrescentic involved glomerulonephritis in infective endocarditisMesangio-capillary glomerulonephritis associated with Q-fever endocarditisRenal consequences of valvular heart diseaseBeitrag zur experimentellen Candidose des Respirationstraktes*The narcotic addict as a medical patientInfective Endocarditis in the Antibiotic EraAmphotericin B Nephrotoxicity with Irreversible Renal FailureFRANK J. TAKACS, M.D., ZYGMUNT M. TOMKIEWICZ, M.D., JOHN P. MERRILL, M.D., F.A.C.P. 1 April 1962Volume 56, Issue 4Page: 610-618KeywordsBacteriaCandidaCapillariesEndocarditisGlomerulonephritisHypersensitivityKidneysLesionsNecrosisPathogenesis Issue Published: 1 April 1962 PDF DownloadLoading ...