Why the study?
Does quinidine improve recovery in patients with ventricular tachycardia?
Does quinidine improve recovery in patients with ventricular tachycardia?
In a historical case series from 1945, treatment with quinidine was associated with recovery in 7 out of 8 treated patients with ventricular tachycardia.
Answers are grounded in this paper and cite their sources.
May support quinidine for ventricular tachycardia recovery; leaves open its role pending modern randomized data.
Article1 October 1945VENTRICULAR TACHYCARDIA—A REPORT OF TEN CASES, EIGHT OF WHICH WERE TREATED WITH QUINIDINE WITH RECOVERY IN SEVENS. L. ZIMMERMANS. L. ZIMMERMANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-4-634 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptReview of the recent literature reveals little dealing with the effects of large doses of quinidine on ventricular tachycardia. No series comparable in size to this one has been noted within the past 15 years. McMillan1recently reported two cases following coronary thrombosis treated successfully with quinidine. Reich2reported a cure with a total of 185 grains given in a period of two and a half days, a dosage believed by him and also by Levine3and Gold4to be the largest dose given in a period of 60 hours. Some of the cases in this series had quinidine in...Bibliography1. MCMILLAN RL: Ventricular tachycardia as a therapeutic problem in coronary thrombosis, South. Med. Jr., 1943, xxxvi, 800. CrossrefGoogle Scholar2. REICH NE: Successful use of a massive dose of quinidine in a case of intractable ventricular tachycardia, Am. Heart Jr., 1944, xxviii, 256. CrossrefGoogle Scholar3. LEVINE SA: Quoted by REICH.2 Google Scholar4. GOLD H: Quoted by REICH.2 Google Scholar5. LEVINEFULTON SAMH: Effect of quinidine sulphate on ventricular tachycardia. Clinical observation, Jr. Am. Med. Assoc., 1929, xvii, 1162. CrossrefGoogle Scholar6. VIKOMARVINWHITE LEHMPD: A clinical report on the use of quinidine sulphate, Arch. Int. Med., 1923, xxxi, 345. CrossrefGoogle Scholar7. FISHBERG AM: Heart failure (2nd edition), 1940, Lea and Febiger, Philadelphia. Google Scholar8. WILLIAMSELLIS CLB: Ventricular tachycardia: an analysis of thirty-six cases, Arch. Int. Med., 1943, lxxi, 137. CrossrefGoogle Scholar9. WOODRUFF LW: Present day uses of quinidine, Illinois Med. Jr., 1934, lxv, 144. Google Scholar10. STEMPIENKATZ SJKH: Quinidine and potassium in the treatment of refractory paroxysmal ventricular tachycardia, Am. Heart Jr., 1942, xxiv, 555. CrossrefGoogle Scholar11. COMEAU WJ: Cardiac drugs—their rational use, Jr. Maine Med. Assoc., 1941, xxxii, 10. Google Scholar12. ZIMMERMAN SL: Transient T-wave inversion following paroxysmal tachycardia, Jr. Lab. and Clin. Med., 1944, xxix, 598. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 1, 1945.From the Cardiological Service, U. S. Veterans Administration, Columbia, South Carolina.Published with the permission of the Medical Director, Veterans Administration, who assumes no responsibility for the opinions expressed or the conclusions drawn by the author. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySARCOIDOSIS WITH FATAL CARDIAC INVOLVEMENT*GEORGE C. ADICKES, M.D., S. L. ZIMMERMAN, M.D., F.A.C.P., EDWARD S. CARDWELL JR., M.D.Measures Used in the Prevention and Treatment of Cardiac Arrhythmias 1 October 1945Volume 23, Issue 4Page: 634-651KeywordsThrombosisVentricular tachycardia Issue Published: 1 October 1945 PDF downloadLoading ...
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S. L. Zimmerman (1945) studied this question.
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