Demonstrates that actin filament motility alters the resonance frequency and rigidity of polymer surfaces as measured by quartz crystal microbalance.
Remains preclinical with no immediate cardiac implications; leaves open extension to in vivo myocardial contractility models.
This contribution reports on the quantification of the parameters of the motility assays for actomyosin system using a quartz crystal microbalance (QCM). In particular, we report on the difference in the observed resonance frequency and dissipation of a quartz crystal when actin filaments are stationary as opposed to when they are motile. The changes in QCM measurements were studied for various polymer-coated surfaces functionalized with heavy meromyosin (HMM). The results of the QCM experiments show that the HMM-induced sliding velocity of actin filaments is modulated by a combination of the viscoelastic properties of the polymer layer including the HMM motors.
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Zalinge et al. (2012) studied this question.
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