Population
Cardiomyopathic (CM) Syrian golden hamster (strain UM-X7.1) and cultured normal hamster cardiac cells
Comparison
12-O-tetradecanylphorbol-13-acetate treatment vs Untreated normal and cardiomyopathic hamster…
Design
Preclinical
Authors
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No immediate clinical implications from this animal study; leaves open PKC-desmin targeting in human cardiomyopathy.
PKC-mediated phosphorylation and subsequent disassembly of desmin filaments may contribute to myofibril disarray in cardiomyopathic cells.
Huang et al. (2002) studied this question.
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