Population
Transgenic (TG) mice with reduced cardiac CapZ protein and wild-type (WT) mice
Comparison
CapZ downregulation and treatment of fiber… vs Wild-type (WT) mice
Design
Preclinical
Authors
Loading...
Warrants no clinical change yet; leaves open CapZ as modulator of myofilament PKC signaling in disease models.
CapZ downregulation increases cardiac myofilament Ca2+ sensitivity and disrupts PKC-mediated control of myofilament activation.
Pyle et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: