Why the study?
Does combining a three-component acellular pertussis/diphtheria/tetanus/poliovirus vaccine with a Haemophilus influenzae type b-tetanus toxoid conjugate vaccine into a single injection affect safety and immunogenicity in infants?
Does combining a three-component acellular pertussis/diphtheria/tetanus/poliovirus vaccine with a Haemophilus influenzae type b-tetanus toxoid conjugate vaccine into a single injection affect safety and immunogenicity in infants?
Combining the vaccines into a single injection is safe and immunogenic, providing adequate immunologic priming despite lower initial antibody levels to H. influenzae type b.
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Supports single-injection combination despite lower post-primary Hib titers; confirms adequate priming with equivalent post-booster responses.
Halperin et al. (1999) studied this question.
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