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August 26, 2012European Heart JournalOpen Access

The editorial reviews the CLARIFY registry finding that women and men with stable CAD have similar clinical outcomes, noting significant methodological limitations including selection bias and high dropout rates.

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Population

>33,000 outpatients with stable coronary artery disease from the CLARIFY registry across 45 countries.

Design

Editorial

Follow-up

1-year

Authors

ESEva Swahn

Discussion

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Overview

Methodological limits in CAD registries warrant cautious interpretation of sex outcomes; underscores need for better female representation and adjudication in future studies.

Structured PICO

P
Population
>33,000 outpatients with stable coronary artery disease (22.6% women) from the CLARIFY registry across 45 countries.

This editorial emphasizes the need for careful methodological planning, including adequate female representation and independent event adjudication, in observational registries like CLARIFY.

Limitations

  • Unclear definition of stable CAD leading to a case mix
  • Selection bias with only 22.6% women recruited
  • High drop-out rate of 6.8% at 1-year follow-up
  • Lack of adjustment for confounding factors like reduced kidney function
  • Events were not adjudicated and only 5% of centres were independently monitored

Cite This Study

Eva Swahn (2012) studied this question.

synapsesocial.com/papers/6a8cde7c634cd4ed8330198bhttps://doi.org/10.1093/eurheartj/ehs276
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Women and men with stable coronary artery disease have similar clinical outcomes: insights from the international prospective CLARIFY registry2012 · 655 citations
  2. 2Gender differences in clinical characteristics, medical management, risk factor control, and long-term outcome of patients with stable coronary artery disease: from the CORONOR registry2020 · 5 citations
  3. 3The Swedish paradox: or is there really no gender difference in acute coronary syndromes?2011 · 18 citations
  4. 4Women, ‘non-specific’ chest pain, and normal or near-normal coronary angiograms are not synonymous with favourable outcomeThe opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.2006 · 72 citations
  5. 5Raising awareness about cardiovascular disease in women2023 · 8 citations