Why the study?
Is doxorubicin hydrochloride therapy associated with renal failure?
Is doxorubicin hydrochloride therapy associated with renal failure?
Doxorubicin hydrochloride therapy may be associated with renal failure, highlighting the need for renal function monitoring in patients receiving this medication.
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May warrant renal monitoring with doxorubicin; leaves open a class effect pending confirmation.
Doxorubicin hydrochloride (Adriamycin) therapy was associated with renal failure in a 78-year-old man. The pathophysiologic findings in this patient were similar to those seen following administration of structural analogues of doxorubicin. Daunorubicin hydrochloride, particularly, is known to cause renal failure in experimental animals. Renal function should be monitored in patients receiving doxorubicin.
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James Burke (1977) studied this question.
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