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April 11, 2006Pediatric Blood & Cancer

MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma

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Authors

ADAndrew M. DonsonMorgan Adams FoundationSASteven O. Addo‐YoboUniversity of Colorado HealthMHMichael H. HandlerMorgan Adams Foundation

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Donson et al. (2006) studied this question.

synapsesocial.com/papers/6a8ce29db2231968f430568ahttps://doi.org/10.1002/pbc.20803
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma2005 · 7,503 citations
  2. 2Clinical Trial Substantiates the Predictive Value of O-6-Methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastoma Patients Treated with Temozolomide2004 · 792 citations
  3. 3Methylation of Discrete Regions of the O 6 -Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene1997 · 218 citations
  4. 4Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group.1995 · 369 citations
  5. 5Phase I Trial of Temozolomide Plus O6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma2005 · 290 citations