Why the study?
Does restoring antithrombin III to pre-dilution concentrations attenuate haemodilution-induced enhancement of coagulation in vitro?
Population
Blood samples from 20 volunteers
Comparison
20% haemodilution with saline supplemented with… vs 20% haemodilution with saline alone, undiluted…
Design
Preclinical
Authors
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AT III supplementation attenuates but does not abolish dilutional hypercoagulability in vitro; hypothesis-generating and should not change practice.
Does restoring antithrombin III to pre-dilution concentrations attenuate haemodilution-induced enhancement of coagulation in vitro?
Maintaining antithrombin III levels during haemodilution attenuates, but does not completely prevent, haemodilution-induced coagulation enhancement in vitro.
Ruttmann et al. (2001) studied this question.
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