Why the study?
Genetic variations may interfere with drug efficacy, and detecting SNPs linked with TNF inhibitor response in rheumatoid arthritis patients could provide an important basis for treatment.
Population
208 clinical samples
Comparison
PCR-HRM curve analysis vs Sanger sequencing
Design
Diagnostic accuracy and assay validation study
Authors
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May aid RA pharmacogenetic testing; leaves open prospective validation before guiding TNF inhibitor selection.
The developed PCR-HRM method provides a highly sensitive, specific, and reproducible tool for genotyping SNPs associated with TNF inhibitor efficacy in rheumatoid arthritis.
Yang et al. (2018) studied this question.
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