Thrombosis Simulation Using a Triphasic Porous Medium Model: Application to Aortic Dissection

This study presents a comprehensive framework for modeling a thrombus growth as a strongly coupled multiphasic porous medium in the context of Type B aortic dissection. Using the theory of porous media, the thrombus is modeled as a triphasic porous aggregate comprising solid, liquid, and nutrient phases. A modified Darcy–Brinkman equation governs fluid flow through the porous structure, while interaction terms in the balance equations facilitate the modeling of mass exchange and other phase interactions. The volume fractions are used to capture the microstructural details. The simulation results demonstrate the thrombus evolution by considering the interplay of factors such as seepage velocity, nutrient volume fraction, and solid volume fraction. Physiological thrombus growth is observed using realistic 3D geometries and boundary conditions. Velocity plots compared with magnetic resonance imaging data show good agreement, with velocities falling within physiological ranges, demonstrating the model’s potential. This model demonstrates the potential for predicting thrombi growth and provides a mechanics-driven perspective on thrombosis modeling with implications for advancing biomechanical research.